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Recent Articles

Retrieval of Foreign Objects and Endosurgical Management of Immature Nonvital Permanent Tooth: A Case Report




 The following report describes a case of nonvital immature permanent tooth with foreign object impacted in the periapical region.

 Case Description

 Treatment of nonvital immature permanent teeth can become complicated with the presence of foreign objects in the canal, which acts a continuous source of pain and infection. The chances of these objects getting impacted periapically increases in case of teeth with open apices. These objects can be easily retrieved if they are located within the pulp chamber but once the object has been pushed apically their retrieval may be complicated. Apical surgery may sometimes be necessary. The following report describes a case of nonvital immature permanent tooth with foreign object impacted in the periapical region. The treatment included retrieval of foreign object through periapical surgery followed by retrograde sealing with MTA. MTA has been advocated for use as an apical barrier because of its sealing capabilities, ability to set in the presence of moisture, its biocompatibility and ability to induce hard tissue formation.


 12 month follow up of the case showed progressive healing clinically and reduction in the size of the periapical lesion.

Role of Proteomics in Identification of New Targets for Drug Discovery And New Biomarkers for Diagnosis and Prognosis of Diseases



Proteomics is emerging technology that is approach to the study of complete complement of protein, trnascriptomics and genomics disparity in large scale as a result of beneficial in drug discovery and development process. A handful of disease biomarker is at present worn usually for population screening disease identification, prediction, monitoring of therapy, and expect of therapeutic response. Unluckily, most of the biomarker goes through from low sensitivity, specificity, and prognostic value mainly to unusual disease in inhabitant’s transmission program. Require new disease biomarkers so as to will additional improve our ability to detect, prognoses, and predict therapeutic response in many types of disease. Novel biomarker discovery and drug target justification are highly complex and supply-rigorous processes, requiring an integral use of various tools, approaches and information. The newly developed proteomic technology features elevated-throughput similar examination of thousands of proteins in individual patients and amount populations and thus opens up the opportunity of given that more details at a global level on the molecular mechanisms. With frequently efficient public databases, bioinformatics can contribute to these processes by providing functional information of target candidates and correlating this information to the biological pathways. In this review, we summarize up to role of drug discovery date advance of bioinformatics application in proteomic research on biomarker discovery and drug target rationale. Particularly, we highlight how Proteomics in identification of new targets for drug discovery and new biomarkers for diagnosis and prognosis of diseases can facilitate the proteomic studies of biomarker identification and drug target validation.  

Toxic Assessment of Potassium Nitrate by Using Cfu-gm Assay



 CFU -GM assay is used to predict myelosuppression of cells caused by chemical induction as well as to find the haematotoxic potential of chemical compounds and the harmful effects of xenobiotics on the proliferative ability of the progenitors. CFU–GM was assessed on different concentrations (4×10-8 mg/ml to 4×10-1 mg/ml) of potassium nitrate in the bone marrow taken from Charles Foster (CF) rats under inverted microscope at 25X magnification. No such effect of the potassium nitrate was seen which could be related to the molecular mechanism of toxic effect of potassium nitrate used in the study.

Efficacy of Plant Extracts and Bioagents Against Three Fruit-rot Fungi of Banana (Musa Paradisiaca L.)



 Efficacy of aqueous extracts of different plant parts and biocontrol agents was tested against the growth of three post-harvest fungal pathogens of banana (Macrophomina phaseolina R-4242, Fusarium oxysporum sp. QJC- 1403 and Nigrospora oryzae NRRL 54030).The plant extracts when applied as pre- and post-inoculation treatments were effective in controlling the growth of the three pathogenic fungi. Extracts of medicinal plants like Azadirachta indica, Eucalyptus globulus and Ocimum sanctum were effective in inhibiting the growth of N.oryzae, while the extracts of Allium cepa and Allium sativum effectively inhibited the pathogenic activity of all three pathogens under investigation. Out of the different bioagents tried, Penicillium citrinum and Streptomyces spp. could effectively control the growth of the three fruit-rot fungi under in vivo conditions

Management of a Young Edentulous Patient Having Papillon Lefévre Syndrome – a Case Report



 Papillon-Lefevre syndrome is a rare autosomal recessive disorder in which the frequently observed manifestations are palmoplantar keratinization and premature loss of both deciduous and permanent teeth. The palmoplantar keratoderma typically has its onset between the ages of 1 and 4 years and severe periodontitis starts at the age of 3 or 4 years. The deciduous teeth frequently fall out by about age five and most of the permanent teeth may also be lost by approximately age 17. In the present, a young, edentulous male of this syndrome having most the characteristic features was treated by modified Complete Denture prosthesis considering his young age and low socioeconomic status. 

Responses of Trapa Natans Against the Soaring Concentrations of Nitrate And Phosphate in a Tropical River Gomti in Lucknow City, India



 The amount of nitrate and phosphate, considered as major inorganic nutrients-cum-pollutants of municipal waste pipes were monitored in the water of a tropical river Gomti in Lucknow city during summer, rainy and winter seasons during 2009. All the samples from the 6 selected sites of Gomti river in the vicinity of this mega city showed the levels of nitrate and phosphate ranged between 14.02-49.13 and 0.16-4.32 mg L-1 respectively, which were beyond the permissible limits (10 mg L-1 NO3 – and 0.1 mg L-1 PO4 3- ) in all the seasons. The maximum values of nitrate and phosphate were recorded during rainy season possibly due to excess runoff of the effluent mixed water through waste pipe lines. Trapa natans (Water chestnut) commonly cultivated aquatic crop in the region was cultured in the 20 L plastic tubs containing Gomti river water, under simulated net house conditions, for 3 weeks. Trapa natans removed nitrate and phosphate upto 71.34 and 74.64% respectively which was significant. Increase of 8.29, 14.59, 70.44 and 24.07% was recorded in the fresh wt., lamina length, protein in fruit and chlorophyll in leaves of Trapa natans respectively.

Numerical Alterations of Different White Blood Cells in Chronic Tobacco Smokers



 In India smoking is a common habit in both rural and urban areas . According to national sample survey 35% of men and 12% of women in India use tobacco in some form or other and it causes various effects on body including blood . Evidence is that accumulating haemostatic factors have a pathogenic role in ischemic heart diseases and stroke ,smoking habit is known to affect several haemostatic heart diseases.

In this study 100 healthy male subjects, 50 chronic smokers and 50 non smokers were assessed for differential white blood cell count .there was decreased neutrophil and basophil count while lymphocyte count was significantly increased to about 30% in smokers from about 24% in non smokers ,while there was no significant changes in other white blood cells.

Objectives- 1.To study the effect of tobacco smoking on different white blood cell count.

2.To establish a correlation between chronic tobacco smoking and its effects on parameters which were studied.

3.To create awareness in tobacco smokers about the effect of tobacco on their health.

Evaluation of Phytochemical Constituents, Antibacterial Activities, Cytopathic and Cytotoxic Effects of Extracts of Tylophora Indica, Curcuma Amada and Urtica Dioica



 Medicinal properties of many Indian herbal plants are yet to be evaluated. The aim of this study was to determine the phytochemical constituents, antibacterial activity, cytopathic and cytotoxicity effects of Tylophora indica, Curcuma amada and Urtica dioica. Various parts of the plants were collected and shade dried. The solvents used for extraction of plants were water, ethanol, methanol, petroleum ether and chloroform. In vitro antibacterial activity was performed by agar disc diffusion method. Normal and multi drug resistant bacterial strains of E.coli, P.aeruginosa were used. Curcuma amada was found to exhibit highest toxicity against both the bacterial strains. But none of the plant exhibited activity over multi drug resistant bacterial strains. Further in vitro cytopathic and cytotoxic effects were determined for Tylophora indica, Curcuma amada and Urtica dioica upon BHK-21 fibroblast cell lines. Cytotoxicity of the plant extracts were determined by calculating the IC50 values. The highest cytotoxicity was found in alcoholic extracts obtained from Tylophora indica with IC50 value ~20µg/ml respectively.

Nitrate Induced Toxicity on Some Haematological Parameters of Charles Foster Rats



 Nitrate can cause multiple physiological effects if allowed to build up to high concentrations in animals. This work is concerned with the study of short term (14 days oral intoxication) nitrate exposure to male and female Charles foster rats that were divided into 4 groups. Ist group was allowed free access to distilled water whereas IInd, IIIrd and IVth groups were provided with water possessing nitrate concentration 45 mgL-1 , 90 mgL-1 and 135 mgL-1 NO3 – respectively. Under these conditions the haematological parameters such as T-RBC count, Hct and Hb showed increasing trend while TLC and blood platelets showed decrease in response to the stress imposed. Certain variations were observed in differential leucocytes count. Nitrate contaminated water seems to have disturbed the physiology and metabolism of experimental mammals (rats).

Nutritional Requirement and Fertilizer Application on Seedling Growth of Tectona Grandis



 Growth performance and biomass of teak (Tectona grandis) seedlings were examined under three different doses of Nitrogen (50, 100 and 150 mg) and Phosphorous (25, 50 and 75 mg) individually as well as in combination with 300g of Farm Yard Manure on sodic soil in Eastern U P in Northern India. Results reveal that a dose of 100mg Nitrogen was required to achieve maximum growth when Teak seedlings were treated with individual doses of Nitrogen and Phosphorous. However, the required dose of Nitrogen was only 50mg when combined with 50 mg of Phosphorous and300g of Farm Yard Manure.