To see the efficacy of which single micronutrient contributed more to the sputum conversion time.
It is double-blind placebo controlled study in which new sputum smear positive pulmonary tuberculosis patients were randomly assigned to receive either placebo or vitamin A or zinc or vitamin & zinc both. Patients were asked to deliver their sputum at weekly interval to measure positivity of bacteria.
A total of 260 patients were enrolled in the study among them 214 patients completed the study. Patient’s mean age was almost similar (p>0.05) at enrolment in all 4 groups (Group A=31, Group B=29.9, Group C=30.6 and Group D=30.9 years). Sputum positivity grade +3 was most prevalent. Patients in Group D (Vitamin A & Zinc) showed earlier sputum conversion time (4.1±1.3; mean±sd) compare with that in the other groups. However, the difference was not significant
Combination of Vitamin A & Zinc supplementation reduces sputum smear conversion time but it failed to show superiority other groups.