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Recent Articles

Prevalence of metabolic syndrome and its association with type 2 diabetes in south Indian patients

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Metabolic syndrome is describes as a clustering of cardiovascular risk factors, such as, abdominal obesity, dyslipidemia, hyperglycaemia and hypertension.  There are so many risk factors are common in Type 2 diabetes and cardiovascular disease, and many of these risk factors are highly correlated with one another. The risk factors of the metabolic syndrome are of metabolic origin and composed of atherogenic dyslipidemia, high plasma glucose level, elevated blood pressure, a prothrombotic state, and a pro inflammatory state. The management of persons with metabolic syndrome should have to focus not only on blood glucose control but also includes approaches for reduction of other cardiovascular disease risk factors. The present study aims to understand the prevalence of metabolic syndrome and its association with type 2 diabetes. The study group included 150 type 2 diabetes patients in the age group ranging between 20-80 years. Waist and hip circumference, BMI, Blood pressure, fasting blood glucose and Cholesterol tests like HDL and Triglycerides was determined. Prevalence of individual risk factor for metabolic syndrome was determined out of 150 patients and 97 patients were observed with high blood pressure, 85 patients were observed with low levels of HDL, 60 patients were observed with central obesity, 45 patients were observed with high triglycerides and all 150 patients were observed with diabetes.

Anti-inflammatory Plants: An Elementary Review

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 The inflammatory action is described as a chain of events that arise in response to noxious stimuli, infection or trauma. Various botanical species and plant parts comprise a diverse array of polyphenolic non-steroidal phytochemicals that are incorporated as floral pigments for the attraction of insects as their pollination. Various autoimmune disorders are defined by distinct inflammation and associated failure of the repair process. Pro-inflammatory molecules like TNF, certain interleukins, prostaglandins and even pathogenic concentration of nitric oxide are instrumental in raising such response. More interestingly, nitric oxide has been shown to have the ability to stimulate COX-2 showing a potential synergism. Bryophyllum pinnatum commonly known in some parts of Africa as “good luck” or “resurrection plant”, often used as an herbal remedy for human disorders, including: hypertension, diabetes mellitus, rheumatism, joint pains, insect bites, arthritis, bruises, wounds, boils, abscesses, headaches, and body pains. The leaves are also used for inguinal lymphadenitis and ear diseases. Rue contains different active compounds, out of them rutin, a flavonoid, is known to have nitric oxide scavenging activity.

Experimental study of the mechanical characteristics of mortars produced with a binder containing two cow dung ashes

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 This study concerns the evaluation of the mechanical characteristics of five mortars produced with a binder containing different proportions of cow dung ash produced in laboratory with objective to its using as additional mineral in the production of mortars. Five other mortars are produced with the same binder containing the same proportions cow dung ash produced traditionally and a standard mortar (control) is also produced with the same binder without any mineral in addition. Some compressive strength tests are carried out on test specimens of mortar (40x40x160 mm3). The compressive strength and chemical characteristic allowed us to estimate and to compare the mechanical characteristics and the pozzolanic activity ratio of both used ashes. The pozzolanic activity ratio of both types of cow dung ash is estimated to 75% and 68% in 28 days. The mechanical characteristics of the mortars containing some cow dung ash produced in laboratory are superior for the greater part to those of the mortars containing some cow dung ash produced traditionally. On the other hand, the medium-term (56 and 90 days) mechanical characteristics of the mortars containing until 15 % of cow dung ash produced in laboratory are equivalent to those of reference mortar.

Cancer Systems Biology & Epidemiology: Application in Target Identification, Combinatorial Drug Therapy & Personalized Medicine

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 Cancer-signalling networks are typically complex which involves gene regulation, signalling, cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy. Computational model of networks make possible to understand the complex behaviour of cancer-signalling network. Correlation between complexity (clustering coefficient) of cancer-signalling network pathway and Cancer Epidemiological data sets (Cancer incidence, Death rate and lifetime risk of cancer) has been validated. Results of study support the initial assumption, that the complexity of network matrices is a direct indicator of cancer threat. Understanding the differential behaviour of regulatory networks during health, disease and in response to drugs play a crucial role to enhance drug development efforts, new target identification, delineation of off-target effects, methods of disease prediction, combinatorial drug regimens and also in development of molecularly targeted personalized treatment.

Build very simple design and cost effective Geiger-Muller counter

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This paper describes our first undergraduate project experience, final report and findings on the subject matter. Initially according to our project title, we were focused on developing a low cost detector which can detect radiation only. To make one of these kinds of detector doesn’t take much and can be prepared at fairly low cost being very common project in nuclear science arena. The Geiger-Muller tube, or GM tube, is an extremely useful and inexpensive way to detect radiation. While the GM tube can only detect the presence and intensity of radiation, this is often all that is needed.

Effect of salinity on some morphophysiological characters of somatic embryogenesis-regenerated plants of pineapple [Ananas comosus (L.) Merr. cv. Smooth Cayenne

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Pineapple in Côte d’Ivoire is going through problems of various origins. Reviving this state imperatively requires both to clean up the plant material and to select varieties which easily adapt to the current pedoclimatic conditions of growing areas. This work assesses the impact of salinity on regenerated pineapple plants by somatic embryogenesis. The tests were carried out in polyethylene bags filled with sea sand, under semi-controlled conditions. Regenerated pineapple plants were watered with six saline solutions (2, 4, 6, 8, 10 and 14 g/L). Control plants were watered with water. The results revealed that salt stress reduces the studied morphophysiological parameters (number of leaves and roots, length of leaves and roots, chlorophyll a, chlorophyll b and total chlorophyll content, the carotenoids content and the relative water content). Pineapple tolerates low salt levels (2 and 4 g/L). However, important disturbances were observed in the metabolism of stressed plants with high levels of NaCl (6 and 10 g/L). As an adaptation strategy to maintain its metabolism from this stress, pineapple responded by accumulating proline. The highest saline content (14 g/L) was found to be lethal for pineapple plants.

i AMF – Centralized database of arbuscular mycorrhizal distribution, phylogeny and taxonomy

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Arbuscular mycorrhizal fungal database, named iAMF (www.amfungi.aurobindo.du.ac.in) is first digital database on biodiversity and phylogeny of these beneficial fungi in India. It provides access to data on 161 species of arbuscular mycorrhizal fungi (AMF) along with comprehensive information on their GPS location of reported occurrence, taxonomy, molecular sequence, phylogeny and bibliography. The database is based on primary data collected by authors through ongoing surveys (year 2009-2017) and secondary data from earlier studies (2008–2016). Data is carefully curated to verify that it corresponds to the reference publication and a valid species name is used. Apart from being ecological meta-analysis data source, it would have significant application in selection of non-indigenous AMF inoculum in agriculture, reforestation, horticultural and land reclamation practices.

In-Silico Characterization of 14-alpha Sterol Demethylase of Aspergillus fumigatus

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 The eukaryotes sterol pathways are extremely conserved and these biosynthetic pathway are very long which includes the synthesis of dolichols, coenzyme Q, heme A, and isoprenylated proteins.14-Demethylase is an essential enzyme of the cytochrome P450 superfamily, which is potential the target of azole antifungals. Predicted results shows that 14-alpha sterol demethylase have molecular weight of 58930.8 Daltons and the theoretical isoelectric point (pI) of 7.64. The negative Grand average of hydropathicity (GRAVY)  index  of  ‐0.125. The Aliphatic index of Aspergillus fumigates 14-alpha sterol demethylase is 89.48. Alpha  helix  (Hh)  accounts   210 amino   acids   of   about   40.08%.   The   extended  strand  (Ee)  had  91  amino  acids accounting 17.37, Beta turn (Tt) made up of 51 amino acids making up 9.73% and random coil (Cc) made up of 172 amino acids accounting 32.82%. The subcellular localization of 14­alpha sterol demethylase Cyp51B was predicted to be a Plasma membrane  protein.

Response of Fertilizer Application (N, P & N+p) on Seedling Growth of Teak (Tectona Grandis Linn.F.)

http://advancejournals.org/journal-of-recent-advances-in-applied-sciences/wp-content/uploads/sites/30/2016/07/28531-34.pdf

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 Performance of seedlings of Tectona grandis were examined for six months under three different doses of N and P (50,100, 150 and 25, 50 , 75 mg respectively) and their combinations for six months under sodic soil condition. Teak seedlings when treated with different doses of N, P, K and their combination exhibited maximum growth at maximum dose of N (150 mg) among individual fertilizer and overall maximum growth for N+P (100 + 75 mg) among combination of fertilizer.

Cfu-gm Asssay as a Diagnostic Test for Toxic Assessment of Chemicals

http://advancejournals.org/journal-of-recent-advances-in-applied-sciences/wp-content/uploads/sites/30/2016/06/281585-89.pdf

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 Pharmaceutical drugs, hazardous chemical compounds and other products must be evaluated for their hematological toxic potential for their safety use. In vitro CFU-GM clonogenic assay is one of the best test systems to evaluate the adverse toxic effects of xenobiotics on the blood forming system. The test involves exposing the mice bone marrow cells to various test substances at different concentrations and estimating the inhibition of the proliferation of the CFU-GM colonies. This technique is best use for determining the human maximum tolerated dose (MTD). It describes the use of in vitro CFU-GM assay for characterizing and predicting hazards to humans.